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Technology

One biopsy.
Full diagnosis.

The first fully automated end-to-end workflow for digital histopathology – from intact tissue to native volumetric data and diagnostic information.

THE IMPACT

From biopsy to diagnosis in under 15 minutes per sample.

120

samples per batch

processed in parallel –
5 bundles of 24

≈ 6 h

hands-on

manual preparation per batch – the only manual step

≈ ¾ FTE

staff time

for sample preparation, then automation takes over

≈ 15 min

per sample

automated staining & native digital imaging

HOW IT WORKS

From biopsy to data in five steps.

A shorter workflow, intact tissue and scalable digital output. 

01

Biopsy

The process starts at the tissue sample – not at the glass slide.

02

Tissue-preserving preparation

Proprietary reagents keep the biopsy intact instead of cutting it into thin sections.

03

Automated staining

Samples are stained automatically in bundles of 24 – no manual handovers.

04

Native 3D light-sheet imaging

A light sheet scans each biopsy from the side, plane by plane, into a full 3D volume.

05

AI analysis & output

LIMAApath visualizes, analyzes and delivers structured results. The tissue stays intact.

MANUAL · sample preparation
FULLY AUTOMATED · staining → native 3D imaging → analysis

THE PLATFORM

Three pillars.
One continuous workflow.

Reagents, hardware and software from a single source – designed as one integrated process instead of isolated steps.

Microscopic view of purple-stained tissue.
01
Tissue & Reagents
  • Proprietary, tissue-preserving preparation 

  • Proprietary protocols & reagents

  • H&E workflow

  • Targeted staining (nanobodies) in development

A conceptual visualization of a tissue sample projected as a series of stacked digital cross-sections over a specimen holder.
02
Automation & Native Digital Imaging

Fully automated processing and native 3D light-sheet imaging.

  • 120 biopsies processed in parallel

  • Automated staining in bundles of 24

  • Light-sheet imaging, one sample at a time

Computer monitor displaying a digital pathology tissue slide.
03
LIMAApath Software

Our intelligent platform orchestrates the workflow from preparation to structured data.

  • Visualization & AI-supported analysis

  • Structured data output

  • Hardware-agnostic integration

A conceptual visualization of a tissue sample projected as a series of stacked digital cross-sections over a specimen holder.

INSIDE THE LAB

Native 3D light-sheet imaging.

A thin sheet of light scans the intact biopsy from the side – plane by plane – and builds a complete 3D volume instead of a single 2D section.

100

virtual slides from a single biopsy

3D

intact tissue volume – not selected 2D planes

100%

of tissue preserved for downstream molecular analysis

WHAT CHANGES

Conventional pathology vs. LIMAA.

Conventional pathology

SAMPLE

Thin 2D sections on glass slides

WORKFLOW

Many manual steps and handovers

TISSUE AFTER ANALYSIS

Largely consumed

DATA

Selected 2D planes

THROUGHPUT

Sequential, slide by slide

LIMAA

SAMPLE

Intact 3D tissue volume

WORKFLOW

Fully automated from staining to imaging

TISSUE AFTER ANALYSIS

Preserved for molecular analysis

DATA

Inherently 3D – up to 100 virtual slides (per biopsy)

THROUGHPUT

up to 120 biopsies / batch, ≈ 15 min / sample

LET’S TALK

More insights
in less time.

Experience real native digital histology in action. Meet us in Cologne or get in touch to learn more.

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